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Saturday, August 1, 2020 | History

2 edition of role of host tissue in skin carcinogenesis found in the catalog.

role of host tissue in skin carcinogenesis

Timo Telaranta

role of host tissue in skin carcinogenesis

an investigation with skin-tumor-resistant and skin-tumor-susceptible mice.

by Timo Telaranta

  • 40 Want to read
  • 26 Currently reading

Published by [Acta Radiologica] in Stockholm .
Written in English

    Subjects:
  • Skin -- Tumors.

  • Edition Notes

    Bibliography: p. 67-74.

    SeriesActa radiologica supplementum -- no. 324., Acta radiologica supplementum -- 324.
    The Physical Object
    Pagination74 p.
    Number of Pages74
    ID Numbers
    Open LibraryOL16601588M

    Bowen’s disease (As-BD) is the most common form of arsenic-induces skin cancers and is characterized by chronicity, multiplicity, and predisposition in sun-spare skin. However, only about 1% of the population exposed to arsenic developped skin cancers, indicating the host immune response plays an important modulatory role in skin carcinogenesis. 2. Physiological role of zinc in the skin Epidermal homeostasis, immune surveillance, zinc signalling Approximately 9 % of the zinc content of the body is associated with the skin, primarily with the epidermis (50–70 mg∙g-1 dry weight) Skin carcinogenesis: the pathogenetic and therapeutic role of zinc.

    These findings show that IL acts as a molecular bridge between IELs and ECs, and reveal a critical host-defensive role for type-2 immunity in regulating EC tissue homeostasis and carcinogenesis. Immune surveillance refers to the capacity of the immune system to sense cellular dysregulation and respond to restore homeostasis.   In a transgenic model of multi-stage squamous carcinogenesis induced by human papillomavirus (HPV) oncogenes, infiltrating CD4 + T cells can be detected in both premalignant and malignant lesions. The lymph nodes that drain sites of epidermal neoplasia contain activated CD4 + T cells predominantly reactive toward Staphylococcal bacterial antigens. HPV16 mice deficient in CD4 + .

    There are shared interests with Arthritis, Connective Tissue and Skin (ACTS) in skin interactions with the environment, skin carcinogenesis, melanoma, and UV radiation. Applications that focus on DNA damage and repair mechanisms in skin cell transformation and neoplasia may be assigned to CE. The Role of Oncogenes in Multistage Carcinogenesis. Authors; Authors and affiliations The effect of aging and interval between primary and secondary treatment in two-stage carcinogenesis in mouse skin, Cancer Pierotti, G. Delia Posta, and M. Barbacid, Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of.


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Role of host tissue in skin carcinogenesis by Timo Telaranta Download PDF EPUB FB2

Acta Radiol Suppl. ; The role of host tissue in skin carcinogenesis. An investigation with skin-tumor-resistant and skin-tumor-susceptible : Telaranta T.

The role of host tissue in skin carcinogenesis; an investigation with skin-tumor-resistant and skin-tumor-susceptible mice. However, defects in the regulatory circuits of the host that control bacterial sensing and homeostasis, or alterations of the microbiome, through environmental changes (infection, diet or lifestyle), may disturb this symbiotic relationship and promote disease.

Increasing evidence indicates a key role for the bacterial microbiota in by:   Current cancer research focuses mainly upon the cancer cells in malignant tumours and is providing a growing database about aberrations in their genetic composition. However, tumours also contain non-cancerous host tissue, referred to as the stroma, which plays an active and indispensable role in tumour growth and influences the virulence of the neoplasm towards the by:   While the normal inflammatory cascade is self-limiting and crucial for host protection against invading pathogens and in the repair of damaged tissue, a wealth of evidence suggests that chronic inflammation is the engine driving by: UVB in sunlight, although far less intense than UVA, plays a more important role in sunburn and skin carcinogenesis, but UVA also contributes to skin carcinogenesis, tanning, some photosensitivity reactions, and aging of the skin.

TGF-β1 plays an important role in the maintenance of tissue homeostasis and has been shown to be overexpressed in a variety of human cancers, including skin cancer (Li et al., ).

In addition. The causal role of human papillomavirus (HPV) in all cancers of the uterine cervix has been firmly established biologically and epidemiologically.

Most cancers of the vagina and anus are likewise caused by HPV, as are a fraction of cancers of the vulva, penis, and oropharynx. HPV and account for about 70% of cancers of the cervix, vagina, and anus and for about 30–40% of cancers of the vulva.

Much has been learned from the study of skin carcinogenesis. The multistep story of cancer was put on firmer footing with the two-step “initiation-promotion” model of chemically induced skin carcinogenesis (Berenblum and Haran, ).

In these ageless experiments, a single small dose of a mutagen, an initiator, irreversibly (genetically. Given the unique embryonic lethal phenotype of Stat3 targeting, tissue-specific knockout and inducible knockout strategies using the Cre-loxP system have been used to elucidate the role(s) of Stat3 in skin biology and skin carcinogenesis.

Loss-of-function studies have been complimented by a Stat3 mouse model expressing a constitutively. Purchase Carcinogenesis - 1st Edition. Print Book & E-Book. ISBNThe concept of cancer “etiology” seems inadequate, at least in its classical use in the pathology of infectious, parasitic, nutrition, metabolic diseases.

We consider the use of the terms carcinogenesis, cancer inducing factors or carcinogenic factors more adequate for what happens during tumor cell transformation, with the mention that the term carcinogenesis defines the initiation of a.

A measure of the reductive PATHWAY TO CARCINOGENESIS: THE ROLE OF BACTERIA Fig. 4 This shows the presence of the Staphylococcus microorganisms after two days of incubation of the malignant tissue using the modified culturing measures.

The grapelike cells are recognizable as the Staphyloccoccus micro-organism. A multi-step process by which a number of distinct phases occur to form malignant skin tumors.

The first step in skin carcinogenesis is initiation, which is a reversible process during genetic mutations, gene activation or inactivation es of initiation are mutations in the v-Ha- ras oncogene or inactivation of the p53 tumor suppressor gene. On the other hand, the constitutive expression of HIF-1α evoked by the mild hypoxic state of the skin has been implicated as a positive factor in the transformation of normal melanocytes into malignant melanoma, one of the most aggressive types of human cancers.

Here we review the uncovered and complex role of HIF-1α in skin carcinogenesis. Therefore, beside viral factors, host responses also play a role in the neoplastic transformation of EBV-infected cells.

HHV-8 is a DNA virus of the herpesviridae family, and HHV-8 infection is strongly associated with Kaposi’s sarcoma. The mechanism, however, of HHVinduced carcinogenesis is very different to that of the related virus, EBV.

Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells. The process is characterized by changes at the cellular, genetic, and epigenetic levels and abnormal cell division is a physiological process that occurs in almost all tissues and under a variety of circumstances.

Led by Dr. Edward Cowen, M.D., the branch conducts both clinical and basic research studying the etiology, diagnosis, and treatment of inflammatory and malignant diseases involving the skin and the host's response to these diseases.

Roles of Stem Cells in Tissue Turnover and Radiation Carcinogenesis Article Literature Review in Radiation Research (6) December with 33 Reads How we measure 'reads'.

Dear Sir, It emerges from the interesting paper by Mancuso et al. on modulation of basal cell carcinoma and squamous cell carcinoma by endogenous estrogen that these hormones have a highly protective role against skin tumorigenesis by diverse agents in two independent mouse models of skin cancer (1).

This is probably true not only for epithelial skin cancer (basal cell carcinoma and squamous. - Race (skin cancer increased in Caucasians as they have decreased melanin to protect from UV light) - Gender (more breast tissue in women, more estrogen as well) - Age (more risk to carcinogen exposure over time, more time for 3 steps of carcinogenesis to occur, more time for multiple mutations to occur).The Arthritis, Connective Tissue and Skin Sciences (ACTS) Study Section reviews basic and clinical research applications dealing with the biology and diseases of joints, connective tissue, and skin.

The List of Reviewers lists all present, whether standing members or temporary, to provide the full scope of expertise present on that date.The multi-step process of human skin carcinogenesis: A role for p53, cyclin D1, hTERT, p16, and TSP-1 Article in European Journal of Cell Biology 86() January with 23 Reads.